CAMBRIDGE, Mass., March 11, 2021 (GLOBE NEWSWIRE) -- Foghorn Therapeutics Inc. (Nasdaq: FHTX), a company pioneering the discovery and development of a new class of medicines targeting genetically determined dependencies within the chromatin regulatory system, today announced that the company will present a poster and chair a panel at the American Association for Cancer Research (AACR) Annual Meeting 2021, which is being held virtually from April 10-15.
Title: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers
Session: PO.ET01.05 - New Targets
Date and time: This poster will be available on demand beginning 8:30AM on Saturday, April 10
Summary: The BRG/Brahma-associated factors (BAF) family of chromatin remodeling complexes regulates the chromatin landscape of the genome. Through its ATP-dependent chromatin remodeling activity, BAF regulates the accessibility of gene-control elements, allowing for the binding of transcription factors. Thus, BAF is a major regulator of lineage- and disease-specific transcriptional programs.
We have discovered and developed a novel series of compounds that potently and selectively inhibit the ATPase components of the BAF complex, SMARCA4 and SMARCA2 (also called BRG1 and BRM, respectively). Pharmacologic inhibition of the BAF complex resulted in lineage-specific changes in chromatin accessibility in cancer cell lines, with uveal melanoma found to be exquisitely sensitive to BAF inhibition. Preclinical data provide the foundation for first-in-human studies of BAF ATPase inhibition as a novel therapeutic to treat uveal melanoma.
Session: SY12.DISC - Next-Generation Epigenetic Drugs
Panel date and time: Wednesday, April 14, 2:30-3:30PM ET
Accompanying presentation: Targeting the BAF Complex in Cancer (available on demand beginning 12:05AM on April 9)
About Foghorn Therapeutics
Foghorn® Therapeutics is discovering and developing a novel class of medicines targeting genetically determined dependencies within the chromatin regulatory system. Through its proprietary scalable Gene Traffic Control® platform, Foghorn is systematically studying, identifying and validating potential drug targets within the chromatin regulatory system. The company is developing multiple product candidates in oncology.
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Fanny Cavalié, Foghorn Therapeutics
Gregory Kelley, Ogilvy
Investor Relations Contact:
Allan Reine, Foghorn Therapeutics
Hans Vitzthun, LifeSci Advisors