United States securities and exchange commission logo

                             October 20, 2020

       Adrian Gottschalk
       Chief Executive Officer
       Foghorn Therapeutics Inc.
       500 Technology Square, Suite 700
       Cambridge, MA 02142

                                                        Re: Foghorn
Therapeutics Inc.
                                                            Amendment 1 to
Statement on Form S-1
                                                            Filed October 19,
                                                            File No. 333-249264

       Dear Mr. Gottschalk :

               We have reviewed your amended registration statement and have
the following
       comment. Please respond to this letter by amending your registration
statement and providing
       the requested information. If you do not believe our comment applies to
your facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.

       Amendment 1 to Form S-1


   1.                                                   Please have counsel
revise its legal opinion to cover the number of shares being offered on
                                                        this registration
 Adrian Gottschalk
Foghorn Therapeutics Inc.
October 20, 2020
Page 2

       You may contact Eric Atallah at (202) 551-3663 or Jeanne Baker at (202)
551-3691 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Courtney Lindsay at (202) 551-7237 or Celeste Murphy at (202) 551-3257
with any
other questions.

FirstName LastNameAdrian Gottschalk                       Sincerely,
Comapany NameFoghorn Therapeutics Inc.
                                                          Division of
Corporation Finance
October 20, 2020 Page 2                                   Office of Life
FirstName LastName